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产品属性：
产品名称 | SPOP-IN-6b dihydrochloride |
规格 | 5 mg、10 mg、25 mg、50 mg |
货号 | EY-01Y18048 |
Cas No.: N/A
别名: N/A
化学名: N/A
分子式: C28H34Cl2N6O3
分子量: 573.51
溶解度: DMSO : 41.67 mg/mL (72.66 mM; ultrasonic and warming and heat to 60°C)
储存条件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM[1].SPOP-IN-6b dihydrochloride shows IC50s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2, and 786-0 cells[1].SPOP-IN-6b (0.1-3.0 μM; 10 hours) dihydrochloride can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content[1].SPOP-IN-6b (40-80 mg/kg; intraperitoneal injection; daily; for 25 days; nude mice) dihydrochloride can slow down the growth of tumour by suppressing SPOP[1].[1]. Guangcai Y, et al. The pyrido-pyrimidines of 2- imines -5- ketone group -2,5- dihydros -1-H- two. CN107141287A.
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