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产品属性：
产品名称 | FR054 |
规格 | 5 mg、10 mg、50 mg、100 mg |
货号 | EY-01Y18050 |
Cas No.: 35954-65-5
别名: N/A
化学名: N/A
分子式: C14H19NO8
分子量: 329.3
溶解度: N/A
储存条件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect[1].FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects[1].FR054 (250 μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells[1].FR054 induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptotic cell death[1].FR054 (1000 mg/kg, ip) suppresses cancer growth in MDA-MB-231 xenograft mice[1].[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.
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