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产品属性：
产品名称 | BPK-21 |
规格 | 5 mg、10 mg、25 mg、50 mg |
货号 | EY-01Y18143 |
Cas No.: 2305052-77-9
别名: N/A
化学名: N/A
分子式: C23H16Cl2F3NO2
分子量: 466.28
溶解度: N/A
储存条件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1].BPK-21 (20 μM) significantly impairs T cellactivation[1]. BPK-21 likely suppresses T cell activation through blockadeof ERCC3 function, which may in turn act downstream or sepa-rately from pathways involved in NFAT and NF-kB activation[1].[1]. Ekaterina V Vinogradova, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29.
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