上海一研生物科技有限公司

产品属性：

Cas No.: 153821-50-2

别名: N/A

化学名: N/A

分子式: C36H52O12

分子量: 676.8

溶解度:

储存条件: -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition:Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

Aquastatin A is a fungal metabolite originally isolated from F. aquaeductuum that has diverse biological activities.1 It is active against S. aureus (MIC = 32 µg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50 = 3.2 µM) and S. aureus fatty acid synthesis (IC50 = 3.5 µM).2 Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 µM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.19 µM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K., et al.Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological propertiesJ. Antibiot. (Tokyo)46(11)1648-1657(1993)

2.Kwon, Y.-J., Fang, Y., Xu, G.-H., et al.Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611Biol. Pharm. Bull.32(12)2061-2064(2009)

3.Seo, C., Soh, J.H., Oh, H., et al.Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060Bioorg. Med. Chem. Lett.19(21)6095-6097(2009)
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