上海一研生物科技有限公司

产品属性：

Cas No.: 481-49-2

别名: N/A

化学名: N/A

分子式: C37H38N2O6

分子量: 606.71

溶解度: ≥ 21.9mg/mL in DMSO

储存条件: N/A
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition:Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

IC50: 90 microM for the antiperoxidant potency Cepharanthine is a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, which is widely used for the treatment of many acute and chronic diseases. The extract of Stephania cepharantha Hayata contains biscoclaurine alkaloids such as cepharanthine, which have been used widely for the treatment of radiation-induced leukopenia.In vitro: Cepharanthine was found to exert antitumor effects by augmenting the immunological responses of the host, or by exerting apoptosis-inducing effects [1]. In vivo: Combined therapy of cepharanthine and S-1 (a new oral antineoplastic agent) showed antitumor effects on human OSCC xenografts and induced apoptotic cells in tumors significantly. Immunohistochemistry results showed TS and DPD expressions down-regulated and OPRT expression up-regulated in tumors treated with cepharanthine plus S-1 [2]. Clinical trial: In order to examine the clinical efficacy of cepharanthin for preventing chemotherapy-caused leukopenia in lung cancer patients, a randomized trial was carried out. The results suggested that administration of cepharanthin had an obvious antileukopenic effect in anticancer treatment, which made it possible to reduce the period of risk for infection and allow effective regimens to be repeatedly administered in a shorter interval [3].
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